Curriculum vitae

Doc. Mgr. Martin Modrianský, PhD.
Date of birth: 11. 11. 1966

Birthplace:

Contact:
Department of Medical Chemistry and Biochemistry
Hněvotínská 3, 775 15 Olomouc, Czech Republic
Tel.: 420-585 632 319, Fax.: +420-585 632 302
E-mail: oregon@tunw.upol.cz

 

Education and postgraduate training:

1987-1992     M.S. in Biophysics and Chemical Physics, Faculty of Science, Palacký University, Olomouc, Czech Republic
1992-1997   Ph.D. in Biochemistry, Department of Biochemistry and Molecular Biology, Oregon Graduate Institute, Portland, Ore., U.S.A.
1998-2000   postdoctoral fellow, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc, Czech Republic
2001-2004   Assistant professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc, Czech Republic
2005-   Associate professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc, Czech Republic

 

Academic appointments:

1998-2000     Research Assistant, Centre for analytical chemistry of molecular structures, Palacký University, Olomouc

 

Research stays:

2000 (3 mos)     University of Pittsburgh
2001 (3 mos)   INSERM U128, Montpellier, France

 

Membership:

1994     Biophysical Society
1998   Czech Chemical Society
1998   Czech Society for Biochemistry and Molecular Biology

 

Awards:

2000     Year 2000 Ruth Crawford Mitchell Czech/Slovak Award, University of Pittsburgh

 

Major Interests:

 

Publications:

Citation index (SCI): 380

Recent publications:

  1. Vrba J., Dvořák Z., Ulrichová J., Modrianský M. (2008) Conventional protein kinase C isoenzymes undergo dephosphorylation in neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine. Cell Biol Toxicol. 24:39-53.
  2. Dvořák Z., Maurel P., Vilarem M.J., Ulrichová J., Modrianský M.  (2007) Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchiceine: focus on PXR, CAR, and GR in primary human hepatocytes. Cell Biol Toxicol. 23:63-73.
  3. Dvořák, Z., Vrzal, R., Ulrichová, J., Pascussi, JM., Maurel, P., Modrianský, M. (2006) Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr Drug Metab. 7:301-13.

  4. Růžička M, Škobisová E, Dlasková A, Šantorová J, Smolková K, Špaček T, Žáčková M, Modrianský M, Ježek P. (2005) Recruitment of mitochondrial uncoupling protein UCP2 after lipopolysaccharide induction. Int J Biochem Cell Biol. 37:809-21

  5. Dvořák Z, Modrianský M, Ulrichová J, Maurel P, Vilarem MJ, Pascussi JM (2005) Disruption of microtubules leads to glucocorticoid receptor degradation in HeLa cell line. Cell Signal. 17:187-96.

  6. Vrba J., Hrbáč J., Ulrichová J., Modrianský M. (2004) Sanguinarine is a potent inhibitor of oxidative burst in DMSO-differentiated HL-60 cells by a non-redox mechanism. Chem.-Biol. Interact. 147:35-47.
  7. Dvořák Z, Modrianský M., Pichard-Garcia L., Balaguer P., Vilarem M.J., Ulrichová J., Maurel P., and Pascussi J.-M. (2003) Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Mol. Pharmacol. 64:160-169.
  8. Arroyo A., Modrianský M., Serinkan F.B., Bello R.I., Matsura T., Jiang J., Tyurin V.A., Tyurina Y.Y., Fadeel B., Kagan V.E. (2002) NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me2SO-differentiated HL-60 cells: Role in phagocytic clearance. J. Biol. Chem. 277:49965-49975.

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