Curriculum vitae

Doc. RNDr. Eva Anzenbacherová, CSc.
Date of birth: 6. 11. 1959

Birthplace: Prague

Contact:
Department of Medical Chemistry and Biochemistry
Hněvotínská 3, 775 15 Olomouc, Czech Republic
Tel.: 420-585 632 321, Fax.: +420-585 632 302
E-mail: anzeneva@tunw.upol.cz

Education

1979-1984     Biochemistry, Faculty of Science,  Charles University, Prague
1984   Rer. Nat. Dr. (Biochemistry) Faculty of Science,  Charles University, Prague
2000   CSc. (Ph.D.) (Chemistry, Biochemistry), Academy of Sciences of the Czech Republic, Prague
2006   Associate professor (Doc.) in Medical Chemistry and Biochemistry, Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc

Positions

1984-1985   Scientific Assistant, Charles University, Faculty of Science, Prague
1985-1994   Scientific Assistant, Academy of Sciences of the Czech Republic,  Inst. Org. Chem. Biochem., Prague
1994-2000 Scientific Assistant,  Inst. Experim. Biopharmaceutics, Acad. Sci.- PROMEDcs Joint Institute, Hradec Králové
2001-2006 Assistant professor, Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc
2006- Associate professor, Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc

Fellowships

1986 (1 month)      Bulgarian Academy of Sciences, Sofia
1997, 1998

1999, 2000

   Detoxication et Physiopathologie Hepatique, Institut National de la Sante Et de la Recherche Medicale, INSERM U128, CNRS, Montpellier, France (group of Reinhard Lange, Ph.D.)
2004   Université de Montpellier 2, France (short term stay)

 

Major interests

Metabolism of xenobiotics; Cytochromes P450, structure and function; Bioanalytical methods

 

PUBLICATIONS          46 original papers
                                78 conference presentations

Citation index (SCI): 270

Recent publications:    

  1. Dvorak Z., Vrzal R., Henklova P., Jancova P., Anzenbacherova E., Maurel P., Svecova L., Pavek P., Ehrmann J., Havlik R., Bednar P., Lemr K., Ulrichova J. (2008) JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes. Biochem Pharmacol 75(2):580-588.

  2. Hudecek J., Hodek P., Anzenbacherova E., Anzenbacher P. (2007) Sructural analysis of cytochromes P450 shows differences in flexibility of heme 2- and 4-vinyls. Biochim Biophys Acta 1770(3):413-419.

  3. Otyepka M., Skopalik J., Anzenbacherova E., Anzenbacher P. (2007) What common structural features and variations of mammalian P450s are known to date? Biochim Biophys Acta 1770(3):376-389.

  4. Jancova P., Anzenbacherova E., Papouskova B., Lemr K., Luzna P., Veinlichova A., Anzenbacher P., Simanek V. (2007) Silybin is metabolized by cytochrome P450 2C8 in vitro. Drug Metab Dispos 35(11):2035-2039.

  5. Červený L., Švecová L., Anzenbacherová E., Vrzal R., Štaud F., Dvořák Z., Ulrichová J., Anzenbacher P., Pávek P. (2007) Valproic acid induces CYP3A4 and MDR1 genes expression by activation of Constitutive androstane receptor and Pregnane X receptor pathways. Drug Metab Dispos 35(7):1032-1041.

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